Moreover, GBI Research’s analyses identified 129 first-in-class programs in active development, constituting 20% of the pipeline for which there is a disclosed molecular target, and acting on 80 distinct first-in-class molecular targets. Although there is significant differentiation in the scientific rationale and clinical prospects across these first-in-class products, the majority of first-in-class targets demonstrate significant preclinical evidence, and alignment to molecular pathophysiological changes. bunion from runningScope – Analysis of innovation in the pain markets (including both nociceptive and neuropathic pain, of both a chronic and acute nature), in the context of the overall pipeline and current market landscape. Also includes analysis of the deals landscape surrounding first-in-class products in pain, and highlights opportunities for in-licensing. – A brief introduction to chronic and acute pain, including subtypes, symptoms, pathophysiology, and an overview of pharmacotherapy and treatment algorithms. – The changing molecular target landscape between the market and the pipeline, and particular focal points of innovation in the pipeline. – Comprehensive review of the pipeline for first-in-class therapies, analyzed on the basis of stage of development, molecule type and molecular target. – Identification and assessment of first-in-class molecular targets, with a particular focus on early-stage programs for which clinical utility has yet to be evaluated, as well as literature reviews on novel molecular targets. – Assessment of the licensing and co-development deal landscape for pain therapeutics, and benchmarking of deals involving first-in-class versus non-first-in-class-products. Reasons to buy – Understand the current clinical and commercial landscape, including a comprehensive study of disease pathogenesis, diagnosis, prognosis and the available treatment options available at each stage of diagnosis.foot surgery high arch
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Select.ender..he.halanx.ones of the toe join to the metatarsal bones of the foot at the interphalangeal joints . 1 :557 Outside the hallux bones is skin, and present on all five toes is a toenail . Omissions? Toe is currently one of four bands on the indite label Macau Picchu, 1 which was formed by the members of Toe, along with the bands Mouse on the Keys, Enemies and Tangled Hair. In humans, the most derived digital feature is the hallux. 16 This article uses anatomical terminology; for an overview, see Anatomical terminology . If you think an injury caused your problem, see the topic Toe, Foot, or Ankle Injuries . Bones of the foot the toe bones are the ones in green, blue and orange Toes are the digits of the foot of a tetrapod . This is your profile URL.